PHCEU 5125: Drug Delivery and Dosage Forms
Announcements!
- Exam 3 is coming up!!! It was moved from Friday, April 19 to
Monday, April 15 thanks to the careful eye of the
SAC representative who noted a medicinal chemistry exam on
that same day and a class vote to move it. It will still be
held in the Auditorium at 10:45 am.
As before...
Please bring your own calculator.
Please sit every other seat and skip rows (ie spread out).
Here is the equation sheet.
PHCEU 5125: Drug Delivery and Dosage Forms, Spring 2002, 4 credit hours
Lectures: MWH, 10:45am to 11:35am in Skaggs Hall 250
Recitation: F, 10:45am to 11:35am; Group I in SH 250, Group II in SH
104
Instructors
Dr. Carol Lim, Course Master
Department of Pharmaceutics and Pharmaceutical Chemistry
Research Park
421 Wakara Way, Room 305
ph. 587-9711
carol.lim@deans.pharm.utah.edu
Dr. Bruce Yu
Department of Pharmaceutics and Pharmaceutical Chemistry
Research Park
421 Wakara Way, Room 311
ph. 581-5133
yby1@utah.edu
Office hours: MWTh 11:50-12:40 Skaggs 252 except on
Jan. 7, 14; March 4, 11; April 1, 8 where office hours
will be in Freeway Lounge.
Teaching Assistants
Charu Kanwal Charu.kanwal@m.cc.utah.edu
421 Wakara Way #306, 581-7120
Anurag Maheshwari
Amaheshwari@pharm.utah.edu
BPRB Rm. 256, 581-7292
Darin Furgeson darin.furgeson@utah.edu
BPRB Rm. 249, 581-7013
Office hours for TAs to be announced.
Grading:
Written Exams: 90%
(4 exams plus 1 take home assignment)
Weekly Homework: 10%
Exams will be in-class (1 hour) unless otherwise indicated.
Grading scale (minimal grades):
90-100% A
80-89% B
70-79% C
Policies:
- Make-up exams (due to illness or approved extenuating
circumstance) will only be given if the instructor is notified prior
to the examination. Failure to take an exam will count as a zero on
that exam.
- Requests for re-grading exam questions may result in the
entire exam being re-graded. Point total errors can be corrected
without re-grading the entire exam.
- Collaboration with other students (ie, cheating) on exams
or on extra credit assignments is not allowed. There will be
consequences for students caught cheating. Students should
confidentially notify the instructor if there is evidence of
cheating by other students.
- Attendance at lectures and recitations are mandatory.
- Homework answers should be written clearly and legibly or
otherwise should be typed.
- Calculus review in Martin (p. 595-601) may be very helpful
to read.
Textbooks:
Selected readings from the following textbooks will be put on closed
reserve at Eccles Library:
- Physical Pharmacy, A. Martin, 4th edition (recommended but not required)
- Pharmaceutical Dosage Forms and Drug Delivery Systems, H. Ansel et al., 7th edition
- Pharmaceutics: The Science of Dosage Form Design, M.E. Aulton, 1998
How does this class help you as a pharmacist?
- Familiarizes the pharmacist with drug delivery systems and dosage forms, creating a foundation of knowledge.
- Solve health-related problems by the use and delivery of pharmaceutical agents
- Ability to help patients, as well as establishing credibility
as a pharmacist
In other words, understanding the fundamental principles of drug
delivery and dosage forms allows for a thorough comprehension of the
drugs that you will be dispensing on a daily basis.
Course Outline
Topic, instructor initials, and number of lectures
- Overview and Intro to Drug Delivery and Dosage Forms (C.L. 3 lectures)
- Dosage form design considerations
- Factors to consider prior to drug formulation- physical/chemical properties, biopharmaceutical/pharmacokinetic properties, therapeutic considerations
- Pharmaceutical excipients
- Routes of administration
- Common dosage forms
- Pharmacogenomics
- Bioavailability/bioequivalence
- Clinical trials
- Solutions of Nonelectrolytes (C.L. 3 lectures)
- Definition and classification of solutions
- Solvents
- Advantages and disadvantages of solution dosage forms
- Solubility, additives, dosages, masking flavors
- Specific oral dosage forms
- Concentration expressions
- Solutions of nonelectrolytes
- Ideal and real solutions- Raoult's Law
- Colligative properties
- MW determination
- Solutions of Electrolytes (B.Y. 2 lectures)
- Elements of chemical thermodynamics
- Electrolytic dissociation
- Activity and activity coefficient
- Debye-Huckel equation
- Colligative properties of electrolytes
- Osmolality
- Ionic Equilibria (B.Y. 1 lecture)
- Definition of acid and base
- Conjugate acid-base pair
- Acid-base equilibria
- Acidity constant
- Buffered and Isotonic Solutions (B.Y. 2 lectures)
- Buffer equation
- Buffer capacity
- Pharmaceutical Buffers
- Buffered isotonic solutions
- Solubility and Distribution Phenomena (B.Y. 2 lectures)
- Solvent-solute interactions
- Solubility of gases in liquids
- Solubility of liquids in liquids
- Solubility of solids in liquids
- Distribution and extraction
- Diffusion and Dissolution (C.L. 3 lectures)
- Diffusion definition
- Pharmaceutical relevance of diffusion, examples
- Steady-state diffusion
- Dissolution
- Noyes-Whitney equation and Hixon-Crowell Cube Root Law
- Drug release
- Diffusion principles in biologic systems
- Tablets: advantages, types, properties, components, etc.
- Capsules: types, advantages of each, components, etc.
- Interfacial Phenomena (C.L. 2 lectures)
- What is an interface?
- Pharmaceutical relevance of interfaces
- Liquid interfaces: surface tension, surface free energy, spreading coefficient
- Adsorption at liquid interfaces
- Emulsions, HLB
- Adsorption at solid interfaces
- Applications of surface active agents
- Colloids (C.L. 2 lectures)
- Introduction to colloids
- Pharmaceutical relevance of colloids, examples
- Types of colloidal systems
- Lyophilic, lyophobic, and association colloids; CMC
- Optical properties of colloids
- Kinetic properties of colloids
- Electric properties of colloids
- Solubilization
- Thermodynamics of micellization
- Krafft point and Cloud point
- Colloidal dosage forms and examples
- Micromeritics (C.L. 2 lectures)
- Micromeritics introduction
- Pharmaceutical relevance of micromeritics
- Particle size and size distribution
- Methods for determining particle size
- Particle shape and surface area
- Methods of determining surface area
- Pore size
- Derived properties of powders
- Powders and granules as dosage forms: advantages, disadvantages, how they are dispensed
- Rheology (C.L. 2 lectures)
- Introduction to rheology
- Pharmaceutical relevance of rheology
- Newtonian systems
- Non-newtonian systems
- Thixotropy
- Determination of rheologic properties
- Viscoelasticity
- Psychorheology
- Applications to pharmacy: ReGelŪ
- Coarse Dispersions (C.L. 3 lectures)
- Definition of coarse dispersions
- Pharmaceutical relevance of coarse dispersions
- Suspensions and examples
- Interfacial properties of suspended particles
- Settling in suspensions
- Formulations of suspensions
- Preparation of suspension
- Bioavailability of suspensions
- Emulsions introduction
- Pharmaceutical applications of emulsions
- Theories of emulsification
- Physical stability of emulsions
- Preservation of emulsions
- Rheologic properties of emulsions
- Microemulsions
- Semisolids
- Aerosols and pharmaceutical examples; advantages, principles
- Kinetics (B.Y. 3 lectures)
- Rates and orders of reactions
- Factors affecting reaction rates
- Catalysis
- Drug degradation
- Binding phenomena (B.Y. 2 lectures)
- Binding affinity and specificity
- Small molecular complexes
- Macromolecular complexes
- Drug Product Design (Guest 1 lecture)
- Prodrugs and drug carriers (includes liposomes, polymer matrix, reservoir devices, microcapsules)
-
Routes of administration (includes ocular, nasal, buccal, pulmonary, oral, transdermal, parenteral, etc)
- Transdermal Drug Delivery (Guest 1 lecture)
- Drug Delivery Issues with Biotechnology Derived Products (Guest 2 lectures)
- Peptides
- Proteins
- Recombinant DNA
- Genes
No classes held from Feb. 2-26, 2002 due to the Olympics.
Tentative exam dates
EXAM 1- Friday, January 25, 2002, Skaggs Auditorium, at 10:45am
EXAM 2- Friday, March 29, 2002, Skaggs 250, at 10:45am
EXAM 3- Friday, April 19, 2002, Skaggs Auditorium, at 10:45am
EXAM 4- during finals week- Wed., May 8, 2002, Skaggs Auditorium, at 10:30am
In class review sessions
January 24, 2002
March 28, 2002
April 18, 2002
May 2, 2002
TA group assignments
Group I: Balls through Laman
Group II: Liu through Zumwait
Group/location
Group I in Skaggs 250
Group II in Skaggs 104
Dates: 1/4/02, 1/11/02, 1/18/02, 3/1/02, 3/8/02, 3/15/02, 3/22/02, 4/5/02, 4/12/02, 4/26/02.
Disclaimer: this information is intended only for the students of
PHCEU 5125 at the University of Utah in the Spring Semester 2002. NOTE
that the notes are password protected to avoid copyright issues. See
the
standard University of Utah disclaimer for more disclaiming.
thomas <cheatham@chpc.utah.edu>
Last modified: January 2002