PHCEU 5125: Drug Delivery and Dosage Forms


Class presentations, old exams, and handouts (password protected)

Announcements!


PHCEU 5125: Drug Delivery and Dosage Forms, Spring 2002, 4 credit hours
Lectures: MWH, 10:45am to 11:35am in Skaggs Hall 250
Recitation: F, 10:45am to 11:35am; Group I in SH 250, Group II in SH 104

Class presentations, old exams, and handouts (password protected)


Instructors

Dr. Carol Lim, Course Master
Department of Pharmaceutics and Pharmaceutical Chemistry
Research Park
421 Wakara Way, Room 305
ph. 587-9711
carol.lim@deans.pharm.utah.edu

Dr. Bruce Yu
Department of Pharmaceutics and Pharmaceutical Chemistry
Research Park
421 Wakara Way, Room 311
ph. 581-5133
yby1@utah.edu

Office hours: MWTh 11:50-12:40 Skaggs 252 except on Jan. 7, 14; March 4, 11; April 1, 8 where office hours will be in Freeway Lounge.

Teaching Assistants

Charu Kanwal Charu.kanwal@m.cc.utah.edu
421 Wakara Way #306, 581-7120

Anurag Maheshwari Amaheshwari@pharm.utah.edu
BPRB Rm. 256, 581-7292

Darin Furgeson darin.furgeson@utah.edu
BPRB Rm. 249, 581-7013

Office hours for TAs to be announced.

Grading:

Written Exams: 90%
(4 exams plus 1 take home assignment)
Weekly Homework: 10%

Exams will be in-class (1 hour) unless otherwise indicated.

Grading scale (minimal grades):
90-100% A
80-89% B
70-79% C

Policies:

Textbooks:

Selected readings from the following textbooks will be put on closed reserve at Eccles Library:
  1. Physical Pharmacy, A. Martin, 4th edition (recommended but not required)
  2. Pharmaceutical Dosage Forms and Drug Delivery Systems, H. Ansel et al., 7th edition
  3. Pharmaceutics: The Science of Dosage Form Design, M.E. Aulton, 1998

How does this class help you as a pharmacist?

In other words, understanding the fundamental principles of drug delivery and dosage forms allows for a thorough comprehension of the drugs that you will be dispensing on a daily basis.

Course Outline

Topic, instructor initials, and number of lectures

  1. Overview and Intro to Drug Delivery and Dosage Forms (C.L. 3 lectures)
    • Dosage form design considerations
    • Factors to consider prior to drug formulation- physical/chemical properties, biopharmaceutical/pharmacokinetic properties, therapeutic considerations
    • Pharmaceutical excipients
    • Routes of administration
    • Common dosage forms
    • Pharmacogenomics
    • Bioavailability/bioequivalence
    • Clinical trials
  2. Solutions of Nonelectrolytes (C.L. 3 lectures)
    • Definition and classification of solutions
    • Solvents
    • Advantages and disadvantages of solution dosage forms
    • Solubility, additives, dosages, masking flavors
    • Specific oral dosage forms
    • Concentration expressions
    • Solutions of nonelectrolytes
    • Ideal and real solutions- Raoult's Law
    • Colligative properties
    • MW determination
  3. Solutions of Electrolytes (B.Y. 2 lectures)
    • Elements of chemical thermodynamics
    • Electrolytic dissociation
    • Activity and activity coefficient
    • Debye-Huckel equation
    • Colligative properties of electrolytes
    • Osmolality
  4. Ionic Equilibria (B.Y. 1 lecture)
    • Definition of acid and base
    • Conjugate acid-base pair
    • Acid-base equilibria
    • Acidity constant
  5. Buffered and Isotonic Solutions (B.Y. 2 lectures)
    • Buffer equation
    • Buffer capacity
    • Pharmaceutical Buffers
    • Buffered isotonic solutions
  6. Solubility and Distribution Phenomena (B.Y. 2 lectures)
    • Solvent-solute interactions
    • Solubility of gases in liquids
    • Solubility of liquids in liquids
    • Solubility of solids in liquids
    • Distribution and extraction
  7. Diffusion and Dissolution (C.L. 3 lectures)
    • Diffusion definition
    • Pharmaceutical relevance of diffusion, examples
    • Steady-state diffusion
    • Dissolution
    • Noyes-Whitney equation and Hixon-Crowell Cube Root Law
    • Drug release
    • Diffusion principles in biologic systems
    • Tablets: advantages, types, properties, components, etc.
    • Capsules: types, advantages of each, components, etc.
  8. Interfacial Phenomena (C.L. 2 lectures)
    • What is an interface?
    • Pharmaceutical relevance of interfaces
    • Liquid interfaces: surface tension, surface free energy, spreading coefficient
    • Adsorption at liquid interfaces
    • Emulsions, HLB
    • Adsorption at solid interfaces
    • Applications of surface active agents
  9. Colloids (C.L. 2 lectures)
    • Introduction to colloids
    • Pharmaceutical relevance of colloids, examples
    • Types of colloidal systems
    • Lyophilic, lyophobic, and association colloids; CMC
    • Optical properties of colloids
    • Kinetic properties of colloids
    • Electric properties of colloids
    • Solubilization
    • Thermodynamics of micellization
    • Krafft point and Cloud point
    • Colloidal dosage forms and examples
  10. Micromeritics (C.L. 2 lectures)
    • Micromeritics introduction
    • Pharmaceutical relevance of micromeritics
    • Particle size and size distribution
    • Methods for determining particle size
    • Particle shape and surface area
    • Methods of determining surface area
    • Pore size
    • Derived properties of powders
    • Powders and granules as dosage forms: advantages, disadvantages, how they are dispensed
  11. Rheology (C.L. 2 lectures)
    • Introduction to rheology
    • Pharmaceutical relevance of rheology
    • Newtonian systems
    • Non-newtonian systems
    • Thixotropy
    • Determination of rheologic properties
    • Viscoelasticity
    • Psychorheology
    • Applications to pharmacy: ReGelŪ
  12. Coarse Dispersions (C.L. 3 lectures)
    • Definition of coarse dispersions
    • Pharmaceutical relevance of coarse dispersions
    • Suspensions and examples
    • Interfacial properties of suspended particles
    • Settling in suspensions
    • Formulations of suspensions
    • Preparation of suspension
    • Bioavailability of suspensions
    • Emulsions introduction
    • Pharmaceutical applications of emulsions
    • Theories of emulsification
    • Physical stability of emulsions
    • Preservation of emulsions
    • Rheologic properties of emulsions
    • Microemulsions
    • Semisolids
    • Aerosols and pharmaceutical examples; advantages, principles
  13. Kinetics (B.Y. 3 lectures)
    • Rates and orders of reactions
    • Factors affecting reaction rates
    • Catalysis
    • Drug degradation
  14. Binding phenomena (B.Y. 2 lectures)
    • Binding affinity and specificity
    • Small molecular complexes
    • Macromolecular complexes
  15. Drug Product Design (Guest 1 lecture)
    • Prodrugs and drug carriers (includes liposomes, polymer matrix, reservoir devices, microcapsules)
    • Routes of administration (includes ocular, nasal, buccal, pulmonary, oral, transdermal, parenteral, etc)
  16. Transdermal Drug Delivery (Guest 1 lecture)
    • Drug Delivery Issues with Biotechnology Derived Products (Guest 2 lectures)
    • Peptides
    • Proteins
    • Recombinant DNA
    • Genes
No classes held from Feb. 2-26, 2002 due to the Olympics.

Tentative exam dates

EXAM 1- Friday, January 25, 2002, Skaggs Auditorium, at 10:45am
EXAM 2- Friday, March 29, 2002, Skaggs 250, at 10:45am
EXAM 3- Friday, April 19, 2002, Skaggs Auditorium, at 10:45am
EXAM 4- during finals week- Wed., May 8, 2002, Skaggs Auditorium, at 10:30am

In class review sessions

January 24, 2002
March 28, 2002
April 18, 2002
May 2, 2002

TA group assignments

Group I: Balls through Laman
Group II: Liu through Zumwait

Group/location
Group I in Skaggs 250
Group II in Skaggs 104

Dates: 1/4/02, 1/11/02, 1/18/02, 3/1/02, 3/8/02, 3/15/02, 3/22/02, 4/5/02, 4/12/02, 4/26/02.

Disclaimer: this information is intended only for the students of PHCEU 5125 at the University of Utah in the Spring Semester 2002. NOTE that the notes are password protected to avoid copyright issues. See the standard University of Utah disclaimer for more disclaiming.


thomas <cheatham@chpc.utah.edu>
Last modified: January 2002