Other physiological changes
•Decrease in Oxygen in blood causes heart rate to increase initially in order to maintain Oxygen transport
•Amount of water in blood plasma decreases after about a week
–Decreases plasma volume without changing volume of red blood cells
–Blood can carry greater quantity of Oxygen
–Prolonged hypoxia stimulates bone marrow to produce more red blood cells
•After a week, heart rate normalizes but stroke volume (volume pumped by left ventricle) decreases, leading to net drop in cardiac oxygen output